Hydroxylamine → HCID 88996196, compound

Participants

Reaction Steps

Hydroxylamine 50% solution in water (236.5 μL of 50% w/v, 3.580 mmol) was added to a stirred solution of di tert-butyl 2-(4-formylphenyl)piperazine-1,4-dicarboxylate (699 mg, 1.790 mmol) in ethanol (20 mL) at ambient temperature. Stirred at ambient temperature for 1 hour. The reaction mixture was concentrated in vacuo and the residue taken up in water and extracted with ethyl acetate (×3). The combined organic extracts were dried over MgSO4, filtered and concentrated in vacuo to give a white foam. Taken onto the next step as is (725.8 mg, assume 100% yield).

Provenance & Evidence