HCID 70818646, compound → HCID 86680970, compound

Participants

Reaction Steps

dioxomanganese (4.455 g, 886.4 μL, 51.24 mmol) was added to a stirred solution of tert-butyl N-[2-fluoro-1-[4-(hydroxymethyl)phenyl]ethyl]carbamate (1.15 g, 4.270 mmol) in dichloromethane (100 mL) and the reaction allowed to stir at ambient temperature for 65 hours. The reaction mixture was filtered through celite and washed with dichloromethane. The filtrate was concentrated in vacuo to give tert-butyl N-[2-fluoro-1-(4-formylphenyl)ethyl]carbamate as a colourless oil (930 mg, 82%). 1H NMR (400.0 MHz, DMSO-d6) δ 1.37 (s, 9H), 4.43-4.46 (m, 1H), 4.54-4.58 (m, 1H), 4.95-5.05 (m, 1H), 7.60 (d, 2H), 7.81 (d, 1H), 7.90 (d, 2H) and 10.00 (s, 1H) ppm; LC/MS m/z 212.0 [M+H]+.

Provenance & Evidence