참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Chloro-6-ethoxybenzo[d]thiazole | HCID 350015 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 6-Ethoxy-2-piperazin-1-yl-1,3-benzothiazole | HCID 28470888 | — |
반응 단계
A mixture of 1.36 mmol 2-chloro-6-ethoxy-benzothiazole (CA=[79071-17-3]), 3.00 mmol of piperazine and 3.00 mmol of triethylamine in 5 ml of tetrahydrofuran in a sealed tube was heated at 160° C. for 5 min under microwave irradiation. The reaction mixture was concentrated, and the residue was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07429585B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-0dae454dc5b1428fb8d1e170ec03ec44 |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
