2-Isopropoxy-5-methylsulfonylbenzoic acid → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(2-methyl-benzothiazol-5-yl)-piperazin-1-yl]-methanone

HRID 33163Notes

Reaction equation

HRID 33163 reaction equation
Cl.[CH3:2][C:3]1[S:4][C:5]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH:18]([O:21][C:22]1[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][C:23]=1[C:24](O)=[O:25])([CH3:20])[CH3:19]>C(#N)C.C(OCC)C>[CH:18]([O:21][C:22]1[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][C:23]=1[C:24]([N:15]1[CH2:14][CH2:13][N:12]([C:9]2[CH:10]=[CH:11][C:5]3[S:4][C:3]([CH3:2])=[N:7][C:6]=3[CH:8]=2)[CH2:17][CH2:16]1)=[O:25])([CH3:20])[CH3:19]

Participants

5

Reactant 2

HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acidHCID 688959552-Methyl-5-piperazin-1-yl-benzothiazole hydrochloride

Product 1

HCID 58906308(2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(2-methyl-benzothiazol-5-yl)-piperazin-1-yl]-methanone

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6342AcetonitrileSolvent

Procedure

Prepared in analogy to example 1.1(b) from 2-methyl-5-piperazin-1-yl-benzothiazole hydrochloride and 2-isopropoxy-5-methanesulfonyl-benzoic acid (example 2.2) in acetonitrile. Trituration in diethyl ether yields the title compound as a yellowish solid.

Sources & evidence

ORD record
ord-c276ef5c8d6e4cc3acfe87ddaeb40ba1
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

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