HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Isopropoxy-5-methylsulfonylbenzoic acid → (2-Isopropoxy-5-methanesulfonyl-phenyl)-(4-quinolin-2-yl-piperazin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Reactant | 2-(Piperazin-1-yl)quinoline hydrochloride | HCID 52988159 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (2-Isopropoxy-5-methanesulfonyl-phenyl)-(4-quinolin-2-yl-piperazin-1-yl)-methanone | HCID 58906321 | — |
Reaction Steps
Prepared in analogy to example 1.1(b) from 2-piperazin-1-yl-quinoline hydrochloride and 2-isopropoxy-5-methanesulfonyl-benzoic acid (example 2.2) in acetonitrile. Trituration in diethyl ether yields the title compound as a yellowish foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429585B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-cc255be60ca9459dbc4d48a836655a38 |
| Source note | uspto-grants-2008_09 |