Citric Acid → HCID 66747923, compound

Participants

Reaction Steps

To a suspension of 2-(2-fluoro-5-methoxy-phenyl)-3-phenyl-acrylonitrile (5.8 g, 22.90 mmol) in ethanol was added sodium borohydride (1.083 g, 28.6 mmol) and stirred at room temperature over night. The mixture was poured on ice-water and after addition of 5% citric acid extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated to obtain an orange oil m=5.68 g (97%).

Provenance & Evidence