Ethyl Acrylate → HCID 66747345, compound

Participants

Reaction Steps

Benzyl trimethylammonium hydroxide (40% in MeOH, 100 μl, 0.22 mmol) was added to a stirred mixture of 2-(3-methoxyphenyl)-3-phenylpropanenitrile (1 g, 4.2 mmol) and ethyl acrylate (0.51 g, 5.1 mmol). After the initial exothermic reaction had subsided the mixture was refluxed for 4 h, cooled to room temperature and extracted three times with DCM. The combined organic layers were washed with water, dried, filtered and evaporated to obtain a pale yellow oil m(CR)=1.06 g that was purified by flash chromatography on 12 g SiO2 using 20% EtOAc in cyclohexane affording 594 mg of product.

Provenance & Evidence