HCID 66747671, compound → HCID 66747577, compound

HRID 331709Notes

Reaction equation

HRID 331709 reaction equation
C(C1(C2C=CC=C(OC)C=2)CNC(=O)C1)C1C=CC=CC=1.CO[C:24](=[O:44])[CH2:25][C:26]([CH2:37][C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)([C:35]#[N:36])[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=1>>[NH2:34][CH2:33][C:29]1[CH:28]=[C:27]([C:26]2([CH2:37][C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[CH2:35][NH:36][C:24](=[O:44])[CH2:25]2)[CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 66747671HCID 66747671, compoundHCID 66747842HCID 66747842, compound

Product 1

HCID 66747577HCID 66747577, compound

Procedure

Prepared in analogy to 4-benzyl-4-(3-methoxy-phenyl)-pyrrolidin-2-one starting from 3-benzyl-3-cyano-3-(3-cyano-phenyl)-propionic acid methyl ester (example 56.2)

Sources & evidence

ORD record
ord-da53490fd5a14c569c26a9274827a2f1
Source dataset
uspto-grants-2014_11
Patent number
US08877794B2

Reaction notes

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