Triphenylphosphine → 2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-5-trifluoromethylpyridine

참여 물질

역할	이름	HCID	투입량
반응물	Triphenylphosphine	HCID 11776	—
반응물	ethyl N-ethoxycarbonyliminocarbamate	HCID 220568	—
반응물	(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol	HCID 2776149	—
반응물	HCID 178516044	HCID 178516044	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	2-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-5-trifluoromethylpyridine	HCID 68442706	51.5%

반응 조건

온도	50 °C

반응 단계

To a solution of (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (95 mg, 0.50 mmol) in THF (6 mL) was added 2-hydroxy-5-trifluoromethylpyridine (90 mg, 0.55 mmol) and triphenylphosphine (197 mg, 0.75 mmol) at ambient temperature under an argon atmosphere. Then diethyl azodicarboxylate (120 μL, 0.75 mmol) was added and the reaction mixture was stirred for 2.5 h at 50° C. Concentration and purification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 0:100) afforded the title compound (86 mg, 51%) as a colourless oil. MS: m/e=335.3 [M+H]+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08877782B2
출처 데이터셋	uspto-grants-2014_11
ORD ID	ord-13519c2595f44822a29a97817f6b1f8f
출처 메모	uspto-grants-2014_11