Isopropylamine → HCID 68445038, compound

HRID 331774Notes

Reaction equation

HRID 331774 reaction equation
[Br:1][C:2]1[C:3]([O:11][CH2:12][C:13]2[C:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:15][O:16][C:17]=2[CH3:18])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7](O)=[O:8].CC1O[N:29]=[C:28]([C:31]2C=CC=CC=2)[C:27]=1COC1C=CC(C(O)=O)=CN=1.C(N)(C)C>>[Br:1][C:2]1[C:3]([O:11][CH2:12][C:13]2[C:14]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[N:15][O:16][C:17]=2[CH3:18])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:29][CH:28]([CH3:31])[CH3:27])=[O:8]

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acidHCID 68442546HCID 68442546, compound

Product 1

HCID 68445038HCID 68445038, compoundYield 86%

Procedure

As described for example 8b, 5-bromo-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (240 mg, 0.6 mmol), instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid, was converted, using isopropylamine instead of methylamine, to the title compound (229 mg, 86%) which was obtained as an off white foam. MS: m/e=430.3/432.2 [M+H]+.

Sources & evidence

ORD record
ord-115efb4bf11b4d35b52170ad87d4fa6c
Source dataset
uspto-grants-2014_11
Patent number
US08877782B2

Reaction notes

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