Hydrochloric Acid → 7a-(6-Fluoro-5-methyl-3-pyridinyl)-hexahydro-1h-pyrrolizine hydrochloride salt

Participants

Reaction Steps

7a-(6-Fluoro-5-methyl-3-pyridinyl)-hexahydro-1H-pyrrolizine (115 mg, 0.52 mmol, from step 18d) was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was crystallized from MeOH/Et2O and dried to afford the title compound (white needles, 92 mg, 69%): mp 170-171° C.; 1H NMR (D2 O, 300 MHz) δ2.12-2.47 (m, 9H), 2.56-2.66 (m, 2H), 3.32-3.41 (m, 2H), 3.77-3.86 (m, 2H), 7.94 (m, 1H), 8.14 (m, 1H); MS (CI/NH3) m/z: 221 (M+H)+ ; MS (CI/NH3): m/z 221 (M+H+). Anal. Calcd for C13H17FN2.HCl: C, 60.82; H, 7.07; N, 10.91. Found: C, 60.83; H, 6.80; N, 10.63.

Provenance & Evidence