HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → (4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-(2-diethylamino-5-methanesulfonyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride | HCID 11521711 | — |
| Reactant | 2-Diethylamino-5-methanesulfonyl-benzoic acid | HCID 57445276 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-(2-diethylamino-5-methanesulfonyl-phenyl)-methanone | HCID 58906301 | — |
Reaction Steps
Prepared in analogy to example 1.1 b) from 2-diethylamino-5-methanesulfonyl-benzoic acid (Example 2.5) and 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (CA=87691-88-1) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid. MS (m/e): 473.4 (M+H+; 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429585B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-e0b778adcc6847c7860d7c0cb261a974 |
| Source note | uspto-grants-2008_09 |