HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenyl-5-trifluoromethyl-isoxazole-4-carboxylic acid → [3-(4-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenyl-5-trifluoromethyl-isoxazole-4-carboxylic acid | HCID 4247808 | — |
| Reactant | 5-(Trifluoromethyl)-3-(4-fluorophenyl)isoxazole-4-carboxylic acid | HCID 68443626 | — |
| Product | [3-(4-Fluoro-phenyl)-5-trifluoromethyl-isoxazol-4-yl]-methanol | HCID 68443889 | 56% |
Reaction Steps
As described for example 128d, 3-(4-fluoro-phenyl)-5-trifluoromethyl-isoxazole-4-carboxylic acid (3.0 g, 11 mmol), instead of 3-phenyl-5-trifluoromethyl-isoxazole-4-carboxylic acid, was converted to the title compound (1.58 g, 56%) which was obtained as a yellow solid. MS: m/e=262.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-6302fd7b904a4079961fb642bb0552db |
| Source note | uspto-grants-2014_11 |