HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → HCID 42629333, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 6-(5-Methyl-3-pyridin-4-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68442291 | — |
| Product | HCID 42629333 | HCID 42629333 | 86% |
Reaction Steps
As described for example 146d, 6-(5-methyl-3-pyridin-4-yl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.64 mol) was converted, using cyclopropylamine instead of 2,2,2-trifluoroethylamine, to the title compound (trituration with tert-butylmethylether, 194 mg, 86%) which was obtained as a white solid. MS: m/e=351.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f921a180283947d2bad5e711987fb6b3 |
| Source note | uspto-grants-2014_11 |