HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione → C-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione | HCID 67157575 | — |
| Reactant | 2-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione | HCID 67158056 | — |
| Product | C-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methylamine | HCID 28750529 | 54% |
Reaction Steps
As described for example 167b, 2-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione (5.9 mg, 18 mmol), instead of 2-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethyl]-isoindole-1,3-dione, was converted to the title compound (2.0 g, 54%) which was obtained as a light yellow oil. MS: m/e=190.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-0b16b280a8644473b9f0a1bf761f4dcf |
| Source note | uspto-grants-2014_11 |