(1-Methylcyclopropyl)amine hydrochloride → HCID 57520473、化合物

HRID 331953ノート

反応式

HRID 331953 の反応式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=1.Cl.[CH3:25][C:26]1([NH2:29])[CH2:28][CH2:27]1>>[CH3:25][C:26]1([NH:29][C:19](=[O:21])[C:18]2[CH:22]=[CH:23][C:15]([O:14][CH2:13][C:3]3[C:4]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)=[N:5][O:6][C:2]=3[CH3:1])=[N:16][CH:17]=2)[CH2:28][CH2:27]1

参加物

3

反応物 2

HCID 12953687(1-Methylcyclopropyl)amine hydrochlorideHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

生成物 1

HCID 57520473HCID 57520473、化合物収率 83%

実験手順

As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 1-methylcyclopropylamine hydrochloride instead of methylamine, to the title compound (97 mg, 83%) which was obtained as a white solid. MS: m/e=362.5 [M−H]−.

出典と根拠

ORDレコード
ord-0ba2737911b94f5ba8393192f471fce2
出典データセット
uspto-grants-2014_11
特許番号
US08877782B2

反応ノート

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