HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66599060, compound → [3-(5-Chloro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66599060 | HCID 66599060 | — |
| Reactant | 3-(5-Chloro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester | HCID 67157573 | — |
| Product | [3-(5-Chloro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-methanol | HCID 67157504 | 73.2% |
Reaction Steps
As described for example 286c, 3-(5-chloro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (1.26 g, 4.7 mmol) was converted, instead of 3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (773 mg, 73%) which was obtained as an off white solid. MS: m/e=224.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d8be5d61d2aa4f5993ac781958b04ea4 |
| Source note | uspto-grants-2014_11 |