HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 332008Generated: October 26, 2026
Formamidine acetate → 4-(Dimethoxymethyl)pyrimidine
https://huagongshe.com/reaction/332008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamidine acetate | HCID 160693 | — |
| Reactant | ((1E)-4,4-dimethoxy-3-oxobut-1-en-1-yl)dimethylamine | HCID 5709580 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(Dimethoxymethyl)pyrimidine | HCID 12440240 | 70.3% |
Reaction Steps
A mixture of (E)-4-dimethylamino-1,1-dimethoxy-but-3-en-2-one (49.6 g, 286 mmol) and formamidine acetate (44.7 g, 429 mmol) was heated at 120° C. for 4 h. After cooling to room temperature the mixture was poured into water and extracted with dichloromethane. The combined organic extracts were then dried over sodium sulfate, filtered and evaporated. Purification by distillation afforded the title product (31 g, 70%) as a colourless liquid. Bp 59-60° C. at 1.3 mbar. MS: m/e=155.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08877782B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-a16d362e903c4f1cbb1e798c1f56208a |
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| Source note | uspto-grants-2014_11 |
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