HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(4-fluorophenyl)-1,2-oxazole-4-carboxylate → 3-(4-Chlorophenyl)-1,2-oxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(4-fluorophenyl)-1,2-oxazole-4-carboxylate | HCID 743179 | — |
| Reactant | Ethyl 3-(4-chlorophenyl)-1,2-oxazole-4-carboxylate | HCID 871629 | — |
| Product | 3-(4-Chlorophenyl)-1,2-oxazole-4-carboxylic acid | HCID 28949454 | 100.1% |
Reaction Steps
As described for example 323d, 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid ethyl ester (57.0 g, 226.5 mmol) was converted, instead of 3-(4-fluoro-phenyl)-isoxazole-4-carboxylic acid ethyl ester, to the title compound (50.7 g, 92%) which was obtained as a light yellow solid. MS: m/e=222.3 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-68334570f1c6441883bdbc557fdcf642 |
| Source note | uspto-grants-2014_11 |