HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluoro-phenyl)-isoxazole-4-carboxylic acid → 3-(4-Chloro-phenyl)-isoxazol-4-ylmethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluoro-phenyl)-isoxazole-4-carboxylic acid | HCID 23447885 | — |
| Reactant | 3-(4-Chlorophenyl)-1,2-oxazole-4-carboxylic acid | HCID 28949454 | — |
| Product | 3-(4-Chloro-phenyl)-isoxazol-4-ylmethanol | HCID 68444382 | 46.1% |
Reaction Steps
As described for example 323e, 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid (40.0 g, 178.9 mmol) was converted, instead of 3-(4-fluoro-phenyl)-isoxazole-4-carboxylic acid, to the title compound (17.3 g, 46%) which was obtained as a light green solid. MS: m/e=210.1 [M+H]′.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-90a85b6ea9424a9f8b65ce7bb6a74aa5 |
| Source note | uspto-grants-2014_11 |