HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 66643758 | — |
| Reactant | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 68444354 | — |
| Product | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68445257 | 96.3% |
Reaction Steps
As described for example 358b, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (510 mg, 1.6 mmol), instead of 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester, was converted to the title compound (458 mg, 94%) which was obtained as a white solid. MS: m/e=296.5 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-06b64eb608bf49a9ba41769675b46a6b |
| Source note | uspto-grants-2014_11 |