HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydroxyamine hydrochloride → 3-trifluoracetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carbaldehyde oxime
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydroxyamine hydrochloride | HCID 443297 | — |
| Edukt | 3-(2,2,2-trifluoro-acetyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carbaldehyde | HCID 58277954 | — |
| Lösungsmittel | Pyridine | HCID 1049 | — |
| Produkt | 3-trifluoracetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carbaldehyde oxime | HCID 131727075 | 81,5% |
Reaktionsschritte
3-Trifluoracetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carbaldehyde (20.0 g) and hydroxylamine hydrochloride (6.1 g) in pyridine (140 ml) were stirred overnight and the reaction then evaporated in vacuo. The residue was partitioned between ethyl acetate and 10% sodium carbonate solution and the combined organic layers dried and evaporated to give 3-trifluoracetyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-carbaldehyde oxime (17.2 g) as a yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07429579B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-49730e9d86ed432089edb9d0712f839e |
| Quellennotiz | uspto-grants-2008_09 |