Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclopropylamine → N-Cyclopropyl-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclopropylamine | HCID 69828 | — |
| 반응물 | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68445257 | — |
| 생성물 | N-Cyclopropyl-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide | HCID 68444722 | 82% |
반응 단계
As described for example 358 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (70 mg, 0.24 mmol) was converted using cyclopropylamine instead of 4-aminotetrahydropyran to the title compound (65 mg, 82%) which was obtained as a white solid. MS: m/e=337.3 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877782B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-65bd4027248c4d0584608637b9c673ab |
| 출처 메모 | uspto-grants-2014_11 |