HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → N-(2-Hydroxy-ethyl)-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68445257 | — |
| Product | N-(2-Hydroxy-ethyl)-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide | HCID 68443349 | 72% |
Reaction Steps
As described for example 358 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.34 mmol) was converted using ethanolamine instead of 4-aminotetrahydropyran to the title compound (82 mg, 72%) which was obtained as a white solid. MS: m/e=341.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-87ee568709594ffa86da42ec24f484da |
| Source note | uspto-grants-2014_11 |