HuagongsheHuagongshe Chemistry Print Report · For research reference only
Magnesium chloride hexahydrate → Vildagliptin Magnesium(II)-Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Magnesium chloride hexahydrate | HCID 24644 | — |
| Reactant | Vildagliptin | HCID 6918537 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Vildagliptin Magnesium(II)-Chloride | HCID 86675510 | — |
Reaction Steps
0.34 g (1.65 mmole) of magnesium(II)-chloride hexahydrate is dissolved in 15 cm3 of 2-propanol at 50° C. under intensive stirring, and 1.0 g (3.3 mmole) of vildagliptin base is added to the solution. The solution is stirred at room temperature for 2 hours and is subsequently evaporated. The remaining crystalline product is washed with propanol and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877799B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-c451687bab2a46079dfc833dbed04ae3 |
| Source note | uspto-grants-2014_11 |