Phenyl glycidyl ether → HCID 71254084, compound

Participants

Reaction Steps

MeLi (1.6 M in Et2O, 108 μl, 0.17 mmol) was added to a solution of the mixture of 6-bromo-9H-carbazole-3-carbonitrile and 9H-carbazole-3-carbonitrile (24.1 mg) in THF (1.0 mL) at −78° C. and stirred for 40 min. Phenyl glycidyl ether (24.1 mg, 0.16 mmol) was added at −78° C. and the reaction was stirred at 45° C. overnight. Upon completion, the solution was quenched with H2O. Ethyl acetate was added and the mixture was washed with H2O, and saturated aqueous NaCl. The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. A small fraction was purified by reverse HPLC to afford the title products P7C3-S154 and P7C3-S155.

Provenance & Evidence