5-Chloro-2-(methylthio)aniline → N-[5-chloro-2-(methylthio)phenyl]-1-benzofuran-2-sulfonamide

HRID 332136Notes

Reaction equation

HRID 332136 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH3:10])=[C:6]([CH:8]=1)[NH2:7].[O:11]1[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[CH:13]=[C:12]1[S:20](Cl)(=[O:22])=[O:21]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH3:10])=[C:6]([NH:7][S:20]([C:12]2[O:11][C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[CH:13]=2)(=[O:21])=[O:22])[CH:8]=1

Participants

3

Reactant 2

HCID 27945775-Chloro-2-(methylthio)anilineHCID 27951721-Benzofuran-2-sulfonyl chloride

Product 1

HCID 57378529N-[5-chloro-2-(methylthio)phenyl]-1-benzofuran-2-sulfonamideYield 60%

Procedure

Following General Procedure B, the title compound (243 mg, 60%) was prepared from 5-chloro-2-(methylthio)aniline (CAS 16423-54-4) (200 mg, 1.15 mmol) and 1-benzofuran-2-sulfonyl chloride (249 mg, 1.152 mmol).

Sources & evidence

ORD record
ord-3785a5ca925a4a34856dc0549b6aa43a
Source dataset
uspto-grants-2014_11
Patent number
US08877804B2

Reaction notes

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