3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole → HCID 67972800, compound

HRID 332192Notes

Reaction equation

HRID 332192 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([SH:21])=[C:6]([NH:8][S:9]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[CH:16]=2)(=[O:11])=[O:10])[CH:7]=1.CC1(C)C2C=CC=CC=2I([C:32]([F:35])([F:34])[F:33])O1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:21][C:32]([F:35])([F:34])[F:33])=[C:6]([NH:8][S:9]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[CH:16]=2)(=[O:11])=[O:10])[CH:7]=1

Participants

4

Reactant 2

HCID 160435723,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxoleHCID 68058433Benzofuran-2-sulfonic acid (5-chloro-2-mercapto-phenyl)-amide

Product 1

HCID 67972800HCID 67972800, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of benzofuran-2-sulfonic acid (5-chloro-2-mercapto-phenyl)-amide (332 mg, 0.98 mmol) in CH2Cl2 (10 ml) at −78° C. was added 3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole (CAS #: 887144-97-0, 354 mg, 1.07 mmol) and the reaction was stirred for 1 h, and was concentrated in vacuo. The crude product was purified by column chromatography on silica gel (CH2Cl2) to give the title compound (375 mg, 94%).

Workup

  1. concentrationwas concentrated in vacuo
  2. customThe crude product was purified by column chromatography on silica gel (CH2Cl2)

Sources & evidence

ORD record
ord-82a2dab9fc8445258abcd13a89536029
Source dataset
uspto-grants-2014_11
Patent number
US08877804B2

Reaction notes

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