HCID 42628942, compound → HCID 68445203, compound

HRID 332278Notes

Reaction equation

HRID 332278 reaction equation
[CH:1]([NH:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[N:8][CH:7]=1)([CH3:3])[CH3:2].[CH3:27]C1ON=C(C2C=CC=CC=2)C=1COC1C=CC(C(NC2CCOCC2)=O)=CN=1>>[CH:1]([N:4]([CH3:27])[C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[C:15]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][O:17][C:18]=2[CH3:19])=[N:8][CH:7]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 42628942HCID 42628942, compoundHCID 575200146-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

Product 1

HCID 68445203HCID 68445203, compoundYield 33%

Procedure

As described for example 50, N-isopropyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide (200 mg, 0.6 mmol), instead of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide, was converted to the title compound (69 mg, 33%) which was obtained as a colourless gum. MS: m/e=366.3 [M+H]+.

Sources & evidence

ORD record
ord-3192c5ad6c1f410cb34754fa487a1fc1
Source dataset
uspto-grants-2014_11
Patent number
US08877783B2

Reaction notes

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