HCID 17998717, compound → HCID 57336135, compound

HRID 332283Notes

Reaction equation

HRID 332283 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=1.Cl.[N:25]1[N:26]=[CH:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][C:29]=12>>[N:25]1[N:26]=[CH:27][N:28]2[CH2:33][CH2:32][N:31]([C:19]([C:18]3[CH:17]=[N:16][C:15]([O:14][CH2:13][C:3]4[C:4]([C:7]5[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=5)=[N:5][O:6][C:2]=4[CH3:1])=[CH:23][CH:22]=3)=[O:21])[CH2:30][C:29]=12

Participants

3

Reactant 2

HCID 17998717HCID 17998717, compoundHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

Product 1

HCID 57336135HCID 57336135, compoundYield 86%

Procedure

As described for example 40, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 5,6,7,8-tetrahydro-(1,2,4)triazolo(4,3-a)-pyrazine hydrochloride instead of (3-amino-piperidin-1-yl)-acetic acid ethyl ester hydrochloride, to the title compound (121 mg, 86%) which was obtained as a white foam. MS: m/e=417.4 [M+H]+.

Sources & evidence

ORD record
ord-d39dbfa6b1fc4d71b91b77efaf84005a
Source dataset
uspto-grants-2014_11
Patent number
US08877783B2

Reaction notes

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