(Oxolan-3-yl)methanamine hydrochloride → HCID 57520100, compound

HRID 332285Notes

Reaction equation

HRID 332285 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=1.Cl.[O:25]1[CH2:29][CH2:28][CH:27]([CH2:30][NH2:31])[CH2:26]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:31][CH2:30][CH:27]2[CH2:28][CH2:29][O:25][CH2:26]2)=[O:21])=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 17750392(Oxolan-3-yl)methanamine hydrochlorideHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

Product 1

HCID 57520100HCID 57520100, compoundYield 81%

Procedure

As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using (tetrahydrofuran-3-yl)methanamine hydrochloride instead of methylamine, to the title compound (103 mg, 81%) which was obtained as a white solid. MS: m/e=394.3 [M+H]+.

Sources & evidence

ORD record
ord-b6f05cf5243948d184956d3e37b22c93
Source dataset
uspto-grants-2014_11
Patent number
US08877783B2

Reaction notes

Loading…