HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate → (3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 22309060 | — |
| Reactant | Ethyl 3-(4-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate | HCID 22309061 | — |
| Product | (3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)methanol | HCID 28473136 | 72.4% |
Reaction Steps
As described for example 88d, 3-(4-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (3.0 g, 12 mmol) was converted, instead of 3-(3-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (1.8 g, 71%) which was obtained as a white solid. MS: m/e=208.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877783B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-e1ff163696cd452aae00f08325f31639 |
| Source note | uspto-grants-2014_11 |