Ethyl 3-(3-fluorophenyl)-5-methylisoxazole-4-carboxylate → [3-(3,4-Difluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol

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Reaction Steps

As described for example 88d, 3-(3,4-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (28.5 g, 107 mmol), instead of 3-(3-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, was converted to the title compound (24.0 g, 48%) which was obtained as a light yellow solid. MS: m/e=226.2 [M+H]′.

Provenance & Evidence