HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminotetrahydropyran → HCID 68933944, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminotetrahydropyran | HCID 419223 | — |
| Reactant | 6-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester | HCID 68441894 | — |
| Reactant | 6-(3-Phenyl-5-trifluoromethyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 68443269 | — |
| Product | HCID 68933944 | HCID 68933944 | 94% |
Reaction Steps
As described for example 90, 6-(3-phenyl-5-trifluoromethyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (100 mg, 0.26 mmol), instead of 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester was converted, using 4-aminotetrahydropyran instead of cyclopropylmethylamine, to the title compound (111 mg, 94%) which was obtained as a white solid. MS: m/e=448.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877783B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-680dbb613b894278a9192f3496d60028 |
| Source note | uspto-grants-2014_11 |