Pyrrolidine → [6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-pyrrolidin-1-yl-methanone

Participants

Role	Name	HCID	Charge
Reactant	Pyrrolidine	HCID 31268	—
Reactant	6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid	HCID 66599213	—
Product	[6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-pyrrolidin-1-yl-methanone	HCID 68444482	98%

Reaction Steps

As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.64 mmol) was converted, using pyrrolidine instead of 2-aminoethyl isopropylether, to the title compound (229 mg, 98%) which was obtained as a colourless. MS: m/e=364.3 [M+H]′.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08877783B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-204ef59cb0ad46f38be83b0b65d655c0
Source note	uspto-grants-2014_11