3-Pyrazolidinone hydrochloride → HCID 68936370, compound

HRID 332452Notes

Reaction equation

HRID 332452 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=1.Cl.[NH:25]1[CH2:29][CH2:28][C:27](=[O:30])[NH:26]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[CH2:13][O:14][C:15]1[N:16]=[CH:17][C:18]([C:19]([N:25]2[CH:29]=[CH:28][C:27](=[O:30])[NH:26]2)=[O:21])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 27337123-Pyrazolidinone hydrochlorideHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

Product 1

HCID 68936370HCID 68936370, compoundYield 5%

Procedure

As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.65 mmol) was converted, using 3-pyrazolidinone hydrochloride instead of 2-aminoethyl isopropylether, to the title compound (12 mg, 5%) which was obtained as a white solid. MS: m/e=375.0 [M−H]−.

Sources & evidence

ORD record
ord-9e60ac82baba4b7abb95ee31448befa0
Source dataset
uspto-grants-2014_11
Patent number
US08877783B2

Reaction notes

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