HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-n-(4-chlorophenyl)acetamide → 2-[(4-Chloro-phenylcarbamoyl)-methyl]-4-cyano-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-n-(4-chlorophenyl)acetamide | HCID 219322 | — |
| Reactant | ethyl 4-cyano-1H-pyrazole-5-carboxylate | HCID 1479416 | — |
| Reactant | 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide | HCID 3421110 | — |
| Reactant | HCID 178468642 | HCID 178468642 | — |
| Product | 2-[(4-Chloro-phenylcarbamoyl)-methyl]-4-cyano-2H-pyrazole-3-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide | HCID 10432754 | — |
Reaction Steps
The title compound was prepared analogously to example 1 with the difference that 2-Bromo-N-(4-chloro-phenyl)-acetamide and 4-Cyano-2H-pyrazole-3-carboxylic acid ethyl ester were used instead of 2-Bromo-N-(5-chloro-pyridin-2-yl)-acetamide and 5-Thiophen-2-yl-2H-pyrazole-3-carboxylic acid ethyl ester in the alkylation step. MS (ESI+): m/e=429, chloro pattern.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429581B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-d2acf5f118894bb9a1bce622322963b8 |
| Source note | uspto-grants-2008_09 |