Ethyl 3-(2,4-difluorophenyl)-5-methylisoxazole-4-carboxylate → [3-(2,4-Difluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol

Participants

Role	Name	HCID	Charge
Reactant	Ethyl 3-(2,4-difluorophenyl)-5-methylisoxazole-4-carboxylate	HCID 18756262	—
Reactant	Ethyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate	HCID 68442729	—
Product	[3-(2,4-Difluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol	HCID 68443314	39%

Reaction Steps

As described for example 84d, 3-(2,4-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (61.9 g, 232 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (20.3 g, 39%) which was obtained as a light brown solid. MS: m/e=284.1 [M+OAc]−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08877783B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-4245ca03690849bc8211792fbda948e4
Source note	uspto-grants-2014_11