HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-propanol → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-propyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-propanol | HCID 4 | — |
| Reactant | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| Product | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-n-(2-hydroxy-propyl)-nicotinamide | HCID 42630541 | 43% |
Reaction Steps
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (200 mg, 0.6 mmol) was converted, using (rac)-1-amino-2-propanol instead of ethanolamine, to the title compound (100 mg, 43%) which was obtained as a colourless gum. MS: m/e=388.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877783B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-5370717c5d314494a6440787ca79b8a3 |
| Source note | uspto-grants-2014_11 |