HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Cyclopropylamine → N-Cyclopropyl-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Cyclopropylamine | HCID 69828 | — |
| Edukt | 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid | HCID 68445257 | — |
| Produkt | N-Cyclopropyl-6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinamide | HCID 68444722 | 82% |
Reaktionsschritte
As described for example 358 g, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (70 mg, 0.24 mmol) was converted using cyclopropylamine instead of 4-aminotetrahydropyran to the title compound (65 mg, 82%) which was obtained as a white solid. MS: m/e=337.3 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08877783B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-1b4c1ba438c844eba854123880f4b62a |
| Quellennotiz | uspto-grants-2014_11 |