HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester → 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester | HCID 66643614 | — |
| Reactant | 3-Pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester | HCID 66643758 | — |
| Product | 3-(5-Fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid | HCID 67157810 | 67% |
Reaction Steps
As described for example 358b, 3-(5-fluoro-pyridin-2-yl)-isoxazole-4-carboxylic acid ethyl ester (1.0 g, 4.23 mmol) was converted, instead of 3-pyridin-2-yl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (587 mg, 67%) which was obtained as a dark brown solid. MS: m/e=207.1 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877783B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-0b8e8fe033f04b3eb1342e210e4465b6 |
| Source note | uspto-grants-2014_11 |