HCID 57701110, compound → HCID 57701121, compound

Participants

Reaction Steps

3-[2-Fluoro-3-(4-fluoro-benzyl)-6-methoxy-phenoxy]-phenylamine P-02. To a 200 mL pressure-resistant vial which contained a mixture of 2-fluoro-1-(4-fluoro-benzyl)-4-methoxy-3-(3-nitro-phenoxy)-benzene P-01 (180 mg, 0.5 mmole) in EtOH (10 mL) was added Ranny Ni (150 mg, excess) at rt. The reaction mixture was flashed 3 times with H2 and then shacked under H2 (40 psi) atmosphere for 2 h. After the catalyst was filtered out, the solvent was removed in vacuo to give 140 mg (85% yield) of desired product P-02.

Provenance & Evidence