反应详情

To a solution of 3-(3-chloro-phenoxy)-4-methoxy-benzaldehyde (12) (393 mg, 1.5 mmol) in methanol (5 ml) was added sodium borohydride (300 mg, 7 mmol) at 0° C. The reaction mixture was stirred at room temperature for 16 h. The mixture was poured into ice-water, extracted with ethyl acetate, washed with water and brine, and dried over Na2SO4. The solvent was removed under vacuum to yield 330 mg (85% yield) of compound (13).

1. extractionextracted with ethyl acetate
2. washwashed with water and brine
3. dry with materialdried over Na2SO4
4. customThe solvent was removed under vacuum