HCID 70869509, compound → HCID 70869425, compound

HRID 332589Notes

Reaction equation

HRID 332589 reaction equation
[C:1]([O:5][C:6](=[O:19])/[C:7](/[CH3:18])=[CH:8]/[C:9]1[O:10][C:11]([C:14]([O:16][CH3:17])=[O:15])=[CH:12][CH:13]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[CH3:17][O:16][C:14]([C:11]1[O:10][C:9]([CH2:8][CH:7]([C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:19])[CH3:18])=[CH:13][CH:12]=1)=[O:15]

Participants

4

Reactant 1

HCID 70869509HCID 70869509, compound

Product 1

HCID 70869425HCID 70869425, compoundYield 91.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 887MethanolSolvent

Procedure

(2E)-(5-Methoxycarbonylfuran-2-yl)-2-methylpropenoic acid tert-butyl ester (2.96 g, 11.1 mmol) was dissolved in methanol (100 mL), 10% palladium/carbon (0.3 g) was added, and the mixture was stirred at room temperature for 2 hours under a hydrogen atmosphere. After completion of the reaction, palladium/carbon was removed by celite filtration, and the solvent was evaporated under reduced pressure to give the title compound (2.72 g).

Workup

  1. customwas removed by celite filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-946a77fb884443e38ff509b9242992c7
Source dataset
uspto-grants-2014_11
Patent number
US08877805B2

Reaction notes

Loading…