3851-91-0 → HCID 86673314, compound

HRID 332594Notes

Reaction equation

HRID 332594 reaction equation
[CH:1]([O:4][S:5]([CH:8]=[CH2:9])(=[O:7])=[O:6])([CH3:3])[CH3:2].[CH:10]([Si:13]([CH:22]([CH3:24])[CH3:23])([CH:19]([CH3:21])[CH3:20])[O:14][CH2:15][CH2:16][CH2:17][NH2:18])([CH3:12])[CH3:11]>CO>[CH:1]([O:4][S:5](=[O:7])(=[O:6])[CH2:8][CH2:9][NH:18][CH2:17][CH2:16][CH2:15][O:14][Si:13]([CH:22]([CH3:24])[CH3:23])([CH:10]([CH3:12])[CH3:11])[CH:19]([CH3:21])[CH3:20])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 122599943851-91-0HCID 86003215HCID 86003215, compound

Product 1

HCID 86673314HCID 86673314, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Vinylsulfonic acid isopropyl ester (0.3 g, 2.00 mmol) obtained in step 1 and 3-triisopropylsilyloxypropylamine (0.9 g, 3.89 mmol) were dissolved in methanol (10 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was purified by silica gel column chromatography to give the title compound (0.65 g).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-a3b9996db52547de9da312a451a69656
Source dataset
uspto-grants-2014_11
Patent number
US08877805B2

Reaction notes

Loading…