Hydrochloric Acid → 7a-(5-Bromo-6-fluoro-3-pyridinyl)-hexahydro-1h-pyrrolizine hydrochloride salt

Participants

Reaction Steps

7a-(5-bromo-6-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was triturated with Et2O and dried to afford the title compound as a white powder (59 mg, 87%): mp 213°-215° C.; 1H NMR D2O, 300 MHz) δ2.15-2.49 (m, 6H), 2.56-2.65 (m, 2H), 3.34-3.42 (m, 2H), 3.78-3.87 (m, 2H), 8.31 (dd, J=2.4, 1.0 Hz, 1H), 8.38 (dd, J=7.8, 2.4 Hz, 1H); MS (CI/NH3) m/z: 285/287 (M+H)+; MS (CI/NH3): m/z 285/287 (M+H+). Anal. Calcd for C12H14BrFN2.HCl: C, 44.81; H, 4.70; N, 8.71. Found: C, 45.04; H, 4.25; N, 8.48.

Provenance & Evidence