Hydrochloric Acid → HCID 86673328, compound

Participants

Reaction Conditions

Reaction Steps

The compound (4.5 g, 20 mmol) obtained in step 1 was dissolved in tetrahydrofuran (30 mL), and 2.5M n-butyllithium/hexane solution (16 mL, 40 mmol) was added dropwise at −78° C. The reaction mixture was stirred at −78° C. for 35 minutes, N,N-dimethylformamide (4 ml) was added dropwise, and the mixture was stirred at −30° C. for 1 hour. The reaction mixture was neutralized with water and 2N hydrochloric acid, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography to give the title compound (1.6 g).

Provenance & Evidence