N,N'-Dimethylethylenediamine → 1,3-Dimethyl-2-(3-methylthiophen-2-yl)imidazolidine

Participants

Reaction Conditions

Reaction Steps

2-Formyl-3-methylthiophene (3.0 g, 23.8 mmol) and N,N′-dimethylethylenediamine (2.3 g, 26.2 mmol) were dissolved in toluene (80 ml), and the mixture was stirred at 120° C. overnight. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography to give the title compound (3.1 g, 15.8 mmol).

Provenance & Evidence