Hydrochloric Acid → HCID 71093241, Verbindung

HRID 332644Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 332644
C(O)=O.[NH2:4][CH2:5][C@@H:6]([C:15]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]2[C:16]=1[CH:17]=[CH:18][C:19](=[O:26])[NH:20]2)[O:7][Si](C(C)(C)C)(C)C.[ClH:27]>CO>[ClH:27].[NH2:4][CH2:5][C@@H:6]([C:15]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]2[C:16]=1[CH:17]=[CH:18][C:19](=[O:26])[NH:20]2)[OH:7]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 71093302(R)-5-(2-Amino-1-(tert-butyldimethylsilyloxy)ethyl)-8-hydroxyquinolin-2(1H)-one formate

Produkt 1

HCID 71093241HCID 71093241, VerbindungAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

(R)-5-(2-Amino-1-(tert-butyldimethylsilyloxy)ethyl)-8-hydroxyquinolin-2(1H)-one formate (0.23 g, 0.61 mmol) was dissolved in hydrochloric acid (5 mL, 4 M solution in dioxane) and methanol (5 mL). The reaction mixture was stirred at RT for 16 hours before concentrating in vacuo. The resulting residue was washed with ethyl acetate and dried in a vacuum oven for 18 hours to afford the title compound (0.15 g, 99%).

Aufarbeitung

  1. concentrationbefore concentrating in vacuo
  2. washThe resulting residue was washed with ethyl acetate
  3. customdried in a vacuum oven for 18 hours

Quellen und Nachweise

ORD-Eintrag
ord-80c7344e52664330819cc9616e1605df
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877774B2

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