Diphosgene → (3R)-1-azabicyclo[2.2.2]octan-3-yl carbonochloridate hydrochloride

Participants

Reaction Steps

To a stirred solution of (R)-3-quinuclidinol (2.5 g, 19.66 mmol) in acetonitrile (200 mL), trichloromethyl chloroformate (3.06 mL, 25.57 mmol) was added dropwise at 0° C. and stirred for 1 hour. The reaction mixture was stirred at RT for 16 hours before concentrating in vacuo to afford the title compound (4.39 g, 98%).

Provenance & Evidence